In short, the most important column on a the screen is the one that comes first in reading order. We've learned that there is an order of importance when we learn to read.These are very important real estate, and it also explains why the 1/3-2/3 split works so well. In essence if you drew a grid on your screen three cells across and three cells down, the points where the lines intersect are the power points. in art it is the golden rule, and photography it is simplified to 'the rule of thirds'. The eye naturally gravitates to 'power points'.However, there are a few principles that we've learned over the years: User Interface design is not a pure science, primarily because people's preferences are different.